Spravato works differently than other antidepressants in its mechanism of action to stimulate areas of the brain to activate neuroplasticity, or the process of brain change. Neurogenesis (“neuro”= “nerve cells” + “genesis” = “creation”) occurs during Spravato and ketamine treatment, which builds new neural pathways and activates new functionality in the brain. This is one of the main reasons patients are finding remission from depression after Spravato treatment when other medicines were not helpful. It is essentially helping patients rewire their brains for contentedness, happiness, and productivity when prior brain circuitry continually evoked anxiety, depression, and fatigue. Spravato patients are quite literally empowering their brains to operate more effectively; potentially better than before their depression began.

Additionally, Spravato has been shown to control the influence of neural pathway signaling downstream which is thought to positively affect future brain chemistry. This is one of the main reasons Spravato patients continue to improve even after treatment. The treatment itself activates areas of the brain that were dormant or damaged or neglected and enables them to repair and continue operating optimally on their own. This enhances the functionality of other brain regions to form repaired synaptic connections with stronger neuronal flow between them.